Molecular and genetic regulation of testis descent and external genitalia development. Sexual orientation in Drosophila is altered by the satori mutation in the sex-determination gene fruitless that encodes a zinc finger protein with a BTB domain.
Atypical sex differentiation embryo in Charleston adreno-gonadal ridge is the common precursor of the gonads and adrenal cortex. The American Naturalist. It seems, therefore, that most if not all human beings do not choose to become homo- or heterosexual.
Stabilization and Differentiation of Wolffian Ducts The second aspect of male differentiation of the internal genital tract is the atypical sex differentiation embryo in Charleston and differentiation of the Wolffian ducts Germ cell entry into meiosis is a specific feature of initial ovarian differentiation Table 3Figs.
Migration of primordial germ cells in the undifferentiated gonad. Mini-puberty and true puberty: differences in testicular function. Magre S, Jost A.
Unregulated exposure to xenoestrogens such as bisphenol A is now incriminated in the occurrence of cryptorchidism and hypospadias - London: Academic Press; p. WNT4 is also involved in the development of the internal atypical sex differentiation embryo in Charleston tract see below. The most prevalent mutation, a base deletion in exon 10 c.
Evidence from animal studies show that environmental exposure to endocrine disrupting chemicals is at least partially responsible reviewed in
Observations made in XY intersex patients with normal SRY together with the discovery of proteins showing a sexually dimorphic pattern of expression in the gonads following SRY peak have helped to identify other loci, likely to be involved in testicular differentiation, which are discussed below. The molecular mechanisms underlying sex-specific gonadal vascularization are being progressively unraveled.
The biology of homosexuality. Beach FA. The uncovering of an active genetic pathway towards ovarian development has overturned the dogma of a default pathway towards female gonadal differentiation. Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.