Spatial genome organization: Contrasting views from chromosome conformation capture and fluorescence in situ hybridization. Verlag von Gustav Fischer; Jena, Germany: J Biol. Adaptive evolution drives divergence of a hybrid inviability gene between two species of Drosophila. They are not randomly positioned in the nucleus, but organised into specific areas called chromosomal territories [ 20 ] that change during the cell cycle [ 2122 ] and development [ 232425 ].
No-bridge of Drosophila melanogaster : portrait of a structural brain mutant of the central complex. Libraries from the samples were sequenced together on one lane in paired-end mode, with a read length of 50 bases. Genes Dev. Genes with male-biased or male-specific expression are observed in greater numbers and with overall higher expression levels compared to genes with female-biased or female-specific expression, a characteristic that is observed in multiple Drosophila species [ 34424346—48 ].
Oxford University Press is a department of the University of Oxford. Soon after, the male positions himself at the rear of the female's abdomen in a low posture to tap and lick the female genitalia.
Frontiers in Cell and Developmental Biology Highly improved gene targeting by germline-specific Cas9 expression in Drosophila. XLSX 33 kb. Sebida: a database for the functional and evolutionary analysis of genes with sex-biased expression. Sex-lethal has been shown to affect the splicing of its own mRNA.
SXL protein functions in sex determination in females by directing the splicing of tra mRNA into a translatable form while in males, where Sxl is absent, tra mRNA is spliced into an isoform containing an exon with stop codons in all reading frames located near the start of the open reading frame that prohibits translation of the full-length mRNA [ 15 , 16 ].
Dudchenko O. Consequently, given the diversity of factors associated with EBRs, it is unlikely that the sequence composition of genomes is solely responsible for genomic instability during evolution and speciation.
Transcript-specific microarrays and RNA-seq have enabled the study of sex-biased gene expression at the transcript level in whole flies and dissected tissues where hundreds of transcript isoforms with sex-biased transcription have been detected [ 41 , 47 , 50—52 ]. The incremental advances made through combined cytogenetic and genomic information in the discovery of the Philadelphia chromosome causing chronic myelogenous leukemia [ 29 , 30 , 31 , 32 , 33 ] and the discovery of the sex-determining gene SRY [ 34 , 35 , 36 , 37 , 38 ].